AhR activation induces immunomodulatory cytokine IL-10, which suppresses an inflammatory response [187]; IL-22, which is a member of the IL-10 family of cytokines, is also primarily produced by Th17 cells under the influence of AhR and is crucial for protection from gram-negative bacteria as well as participates in the progression and pathogenesis of autoimmune diseases [189]. This evidence concerns the gene IL10 and autoimmune disease.