For instance, it is reported that in mice with an AhR knockout, hypertrophic changes in the heart develop, as does cardiomyopathy with decreased cardiac output, possibly owing to cardiomyocyte hypertrophy [21] or to elevated blood pressure and increased plasma concentrations of endothelin 1 (ET-1) and angiotensin II [290]. The gene discussed is EDN1; the disease is cardiomyopathy.