Recently, exome sequencing on 26 androgen insensitive syndrome (AIS) type II genital skin fibroblasts, who are an AR mutation-negative group, revealed heterozygous variants in DAAM2 in two unrelated individuals with partial AIS who were born with hypospadias, a micropenis, no Mullerian structures, and normal plasma testosterone levels [30]. The gene discussed is DAAM2; the disease is androgen insensitivity syndrome.