For instance, Lee and colleagues used blood samples from AD patient and found associations between the expression of GPBP1, also known as Vasculin, in both vascular wall and plasma, crucial for atherosclerosis, and SETDB2, a SET-domain-containing lysin methyltransferases involved in lipid metabolism via the glucocorticoid-dependent pathway. This evidence concerns the gene GPBP1 and Alzheimer disease.