In addition to APOE4, other genes associated with AD risk, such as CLU, PICALM, CD33, MS4A4, MS4A6A, TREM2, ABCA7, CD2AP, and EPHA1, have been identified in GWASs using meta-analysis methods involving both AD patients and non-AD populations (Table 1). This evidence concerns the gene APOE and Alzheimer disease.