In a later study involving a MYC-driven HCC mouse model, they showed that depletion of MYC mRNA and protein expression via MYC antisense oligonucleotides led to decreased HCC cancer cell proliferation, increased cancer cell apoptosis and senescence, and remodeling of the tumor microenvironment via the recruitment of CD4+T cells, highlighting the antitumor effect of CD4+T cells in HCC tumor regression [105]. Here, CD4 is linked to hepatocellular carcinoma.