GANAB, TGFβRII, NF-κB, Cortactin, Septin 2, IFI35, ARHGDIA, and Cofilin 1 abundance in EVs isolated from the peripheral blood of healthy and MS patients was determined by Western blotting, the densitometric analysis highlighting a significant difference between HC- and MS-patient-derived EVs as well as between the lEVs and the sEVs. This evidence concerns the gene SEPTIN2 and myeloid sarcoma.