IFI35 and myeloid sarcoma: In general, a significant high quali-quantitative variability in the content of vesicles isolated from MS patients was observed, with some differentially expressed characterizations: (I) ARHGDIA and Cofilin 1 were present only in the small vesicles; (II) patient 3 displayed the highest amount of considered proteins from the large vesicles, except for IFI35 which is more expressed in the small vesicles; (III) in the small vesicles from HCs, the molecules were less abundant than in large ones (Table 1).