PPARA and colorectal cancer: Furthermore, PTPRO could inhibit colorectal cancer development and metastasis by regulating the Akt/mTOR/sterol regulatory element binding protein 1 (SREBP1)/acetyl-CoA carboxylase 1 (ACC1) and MAPK/peroxisome proliferator-activated receptor alpha (PPARα)/peroxisomal straight-chain acyl-CoA oxidase 1 (ACOX1) signaling pathways, thereby reprogramming lipid metabolism [255].