MMP2 and cancer: The presence of the transcription factor STAT1 (Signal transducer and activator of transcription 1) and the enzyme MMP2 (matrix metallopeptidase 2) in cluster 2 (depicted in green in Figure 5c) implied roles for inflammation and extracellular matrix remodeling, respectively, in these cells, two processes that are interlinked and known to support cancer progression [43] and drug resistance [44].