TAS2R4 and malignant colon neoplasm: Differential expression analysis results revealed that compared to normal colon tissue, colon cancer samples exhibited elevated expression levels of TAS2R1, TAS2R4, TAS2R5, TAS2R14, TAS2R19, TAS2R20, and TAS2R38 (p < 0.05), with the exception of TAS2R60, which was downregulated (Figure 1A).