HIF1A and cervical cancer: The presence of the HSP90 chaperone is well documented in cervical cancer tissue and cell lines [83,84,85]; one possible explanation for the increase in HIF-1α protein in the subclone shSiHa is that by decreasing the amount of pSTAT5, the HSP90 is released; then, it is available to stabilize HIF-1α, increase protein stability, and in consequence increase the amount and the mean fluorescence intensity.