CASP8 and tuberculosis: Previously, we demonstrated that a decrease in body weight resulting from a reduction in body fat increases pulmonary pathology and the risk of TB activation in a low-grade Mtb (laboratory-adapted strain Mtb H37Rv) infection using a transgenic, inducible “fatless” murine TB model system, the FAT-ATTAC (fat apoptosis through targeted activation of caspase 8) mouse [9].