Partial least squares discriminant analysis (PLS-DA) presented a distinct metabolic fingerprint between the time of hypertension establishment (one week and three weeks for the AngII and DOCA–HS models, respectively) and the endpoint of the in vivo experiments (five weeks and seven weeks for the AngII and DOCA–HS models, respectively) (Figure 4A,B). Here, AGT is linked to hypertensive disorder.