The Scutellaria baicalensis Georgi polysaccharide named SP2-1 increased the protein expression of ZO-1 and Occludin in the colon of dextransulfate sodium (DSS)-treated mice [28]; Sargassum fusiforme polysaccharides increased the mRNA and protein expression of ZO-1 and Occludin in the colon of mice with DSS-induced colitis [29]; pine pollen polysaccharides also promoted the expression level of ZO-1, Occludin, and Claudin-1 of colonic tissue in mice with DSS-induced ulcerative colitis [30]. Here, CLDN1 is linked to ulcerative colitis.