APOE and atherosclerosis: In a preclinical model of atherosclerosis, such as apolipoprotein E knockout (ApoE-KO) mice fed with high-fat diet, P. notoginseng freeze-drying powder (containing ginsenosides R1, Rb1, Rg1, Re, and Rd, total concentration 85.3%), at the dose of 60 mg/kg i.p. for 8 weeks, reduced plaque area and lipid deposition in the atheroschlerotic lesions in the aorta [50,51].