CCNB1 and obesity due to melanocortin 4 receptor deficiency: On the other hand, IF targets the obesity-induced parameters, lowering body weight and blood glucose/cholesterol to destroy the obesity-associated microenvironment of TNBC with downregulated cyclin B1/vimentin and Mφ accumulation followed by decelerated TNBC progression and mortality (Figure 9C, green arrows).