IGF1 and hydrops fetalis: The HF-risk-modifying impacts of fasting may include altering the human growth hormone/insulin-like growth factor-1 axis [12,13], reducing anemia [12], removing excess sodium and other circulating analytes [8,14,15], activating autophagy [16,17,18,19,20,21], and shifting energy source from glucose to fatty acid-derived ketones [22,23,24,25,26].