Astrocyte ablation by L-AAA resulted in alterations in behavioral tests (such as novel object recognition test, forced swimming test, and TST) and the occurrence of ameboid microglia, accompanied by increased TNF-α, IL-6, and IL-10 levels, suggesting that astrocytes are an important element in depression-related neuroinflammation [36]. This evidence concerns the gene IL6 and major depressive disorder.