The NF-κB is part of both canonical (e.g., TNFR and IL-1R) and non-canonical (e.g., BAFFR) pathways that can promote the initiation and progression of castration-resistant prostate cancer [117], and as we mentioned earlier, Snail is a master regulator of EMT in prostate cancer [133]. This evidence concerns the gene SNAI1 and Familial prostate cancer.