In contrast, the ZnT-Down pattern has also been observed for ZnT4, 5, and 6 in prostate cancer tissue, and ZnT1, ZnT2, ZnT5, ZnT6, and ZnT7 in prostate cancer cell lines, including LNCaP, PC3, DU145, and others, such as C4-2B (from lymph node and moderated tumorigenic potential) [57] (Table 2), but their pathological mechanisms are largely unknown. This evidence concerns the gene SLC30A2 and Familial prostate cancer.