SLC39A4 and familial pancreatic carcinoma: Conversely, depletion of ZIP4 by RNAi reduces cell proliferation, migration, and the invasion of pancreatic cancer cell lines [134] or reverses EMT transition, increasing epithelial marker E-cadherin and reducing the mesenchymal marker vimentin in human nasopharyngeal carcinoma cells [120], suggesting ZIP4 as a potential therapeutical target for various type of cancers.