VEGFA and Familial prostate cancer: On the other hand, ZIP4 can facilitate angiogenesis by increasing the expression of the vascular endothelial growth factor (VEGF) and its receptor neuropilin-1 (NLR-1), which (both NLR-1 and VEGFR), in other studies, have been involved in the progression and metastasis of prostate cancer [135,136,137,138].