In this review, we summarize the principal dysregulation of zinc transporters in prostate cancer cell lines, prostate cancer tissue, a mouse model of prostate cancer, and in silico analyses of the microarray from a prostate cancer mice model (Nkx3.1;Pten) and a human RNAseq database (cBioPortal). This evidence concerns the gene NKX3-1 and prostate carcinoma.