The diagnosis of CD in adults requires a positive serology for immunoglobulin A (IgA), anti-transglutaminase 2 (TG2), and total IgA, along with evidence of villous modifications on a small intestine biopsy, such as varying degrees of villus atrophy, mucosal inflammation, and crypt hyperplasia [2,27]. The gene discussed is CD79A; the disease is Cowden disease.