MTHFR and ventricular septal defect: Likewise, rs2066470 (homozygous: OR = 4.28), rs1801133 (homozygous: OR = 2.28), and rs1801131 (heterozygous: OR = 1.75; homozygous: OR = 3.45) polymorphisms in pediatric MTHFR gene were observed to be associated with VSD.