As previously mentioned, UN, oxidative stress, and inflammation co-exist very closely, so to evaluate hypothalamic inflammation and its possible disruption in the UN condition and its treatment with the BC, TNFa and Il-1β gene expression was measured; BC treatment presented a tendency to downregulate TNFa in UN animals but, on the other hand, a tendency to increase IL-1β (Figure 10C,D). Here, TNF is linked to breast cancer.