In the current study, the observations of (i) increased fission and fragmentation of mitochondria in the brain, liver, and WAT, (ii) decreased NRF2 (an antioxidative stress marker), and (iii) increased TNF-α (an inflammation marker) corroborate Kabra’s study that increased fission and fragmentation of mitochondria have been associated with hyperglycemia-induced ROS overproduction in both mouse and human islets [28]. The gene discussed is TNF; the disease is Hyperglycemia.