TH and early-onset autosomal dominant Alzheimer disease: The human neuroblastoma SH-SY5Y cell line, possessing catecholaminergic and neuronal properties which express tyrosine hydroxylase and dopamine β-hydroxylase to synthesize dopamine and noradrenaline, is often regarded as an important in vitro model for investigating the intracellular molecular pathways of neural cells and developing neuroprotective drugs for neurodegenerative diseases, especially Alzheimer’s disease (AD) or PD [32].