VEGFA and macular retinal edema: Biological factors, including cytokines and angiogenic factors, detected in the patients with macular edema in the course of the RVO include: interleukin-1β (IL-1β), IL-6, IL-8, IL-12, IL-15, IL-17, IL-23, TGF-β, VEGF, basic fibroblast growth factor (bFGF), chemokine CXC motif ligand 10 (CXCL-10), chemokine ligand 2 (CCL2), platelet-derived growth factor (PDGF-AA), serum amyloid A (SAA), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular endothelial growth factor receptor 2 (sVEGFR-2) (Table 2) [30].