Further alterations common to both AD and epileptic syndromes have been identified in animal models, including increased Nav1.6, decreased Nav1.1 in GABAergic inhibitory interneurons, increased L-type Ca2+ channels, and decreased levels of calbindin, which is implicated in intracellular calcium transport in the dentate gyrus [27]. The gene discussed is SCN8A; the disease is epilepsy syndrome.