IL6 and fibromyalgia: On the other hand, the involvement of cytokines such as IL-1β, IL-6, IL-10, and TNF-α can also disrupt metabolic homeostasis in the musculature leading to muscle loss (specifically, IL-6) as well as alter levels of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol in the hypothalamic–pituitary–adrenal axis, resulting in chronic fatigue symptoms and a fibromyalgia-like condition [19,20,21].