The same study also compared HSPA1A gene genotypes and demonstrated that the 190 G/C genotype of the HSP70-1 gene occurred with comparable frequency in both healthy individuals and POAG patients, while the 190 C/C genotype was more frequent in patients with an increased nerve fibre index (NFI) in polarimetric nerve fibre layer thickness analysis, confirming the involvement of the 190 C/C genotype in the progression of POAG [59]. The gene discussed is HSPA1B; the disease is open-angle glaucoma.