FLG and Eczematoid dermatitis: The first hypothesis concerns an imbalance of the adaptive immune system (imbalance of T cells, particularly T helper cell types 1, 2, 17, and 22 and also regulatory T cells with Th2 differentiation of naive CD4+ T cells predominates); the second hypothesis concerns a defective skin barrier (mutations in the filaggrin gene; with gene defects, less filaggrin is produced, leading to skin barrier dysfunction and transepidermal water loss, which causes eczema) [2].