Fuchs’ Endothelial Corneal Dystrophy (FECD, herein shorted as Fuchs) is a corneal disease characterized by the progressive degeneration of corneal endothelial cells, leading to the abnormal deposition of ECM components (mainly fibronectin and type-1 collagen), which consist in excrescences in Descemet’s membrane known as corneal guttae [1,2,3,4,5]. The gene discussed is FN1; the disease is Fuchs endothelial corneal dystrophy.