Gender analysis showed that PR transcripts (A) were unchanged in Fuchs’ dystrophy (p > 0.05); ERα transcripts (B) were significantly upregulated in Females (p < 0.0005) with respect Males; and finally, the expressions of AR (C, p < 0.0005) and SHBG (D, p < 0.005) transcripts were significantly deregulated in Fuchs disease vs. control. The gene discussed is SHBG; the disease is Fuchs endothelial corneal dystrophy.