Considering the significant role of the Kv7.2 and Kv7.3 channels in regulating neuronal excitability, channel activation, in the case of LoF phenotypes, represents a promising tool for treating or preventing neurological disorders associated with neuronal hyperexcitability (e.g., epilepsy, neuropathic pain, ischemic stroke, amyotrophic lateral sclerosis). Here, KCNQ2 is linked to epilepsy.