It was noted that, depending on the structure, polyhalogenated benzimidazoles downregulate native and recombinant CK2 from various sources, discriminate between different CK2 isoforms in vitro, inhibit other classical eukaryotic protein kinases (e.g., PIM, CDK9, DYRK, PKD, or atypical RIO1) with varying degrees of selectivity and potency, and induce apoptosis in numerous cancer cell lines (e.g., HeLa, CML, Mcl-1, and MCF-7). The gene discussed is WEE1; the disease is cancer.