The first one was apelin-17 (3, also known as K17F), a truncated form of apelin, which is a natural agonist ligand of the apelin receptor (APJ receptor that belongs to the large family of G-protein coupled receptors, GPCRs) with potential applications for the treatment of cardiovascular diseases, glucose regulation and the development of blood vessels [61]. The gene discussed is APLNR; the disease is cardiovascular disorder.