It was demonstrated that cGAS activation causes autoimmune diseases in Trex1-/- and DNaseII-/- mice, suggesting that inhibiting cGAS could prevent and treat some human autoimmune diseases triggered by self-DNA [115]; and tonic prime-boost of STING signaling mediates Niemann–Pick disease type C [116]. The gene discussed is CGAS; the disease is Niemann-Pick disease type C.