Xanthohumol in hops treats a variety of cancers, due to the inhibition of cancer cell growth and proliferation by regulating multiple signaling pathways (Akt, AMPK, ERK, insulin like growth factor binding protein 2 (IGFBP2), NF-κB, STAT 3) and proteins (Notch1, caspases, MMPs, Bcl-2, cyclin D1, oxidative stress markers, tumor-suppressor proteins, and miRNAs) [58]. This evidence concerns the gene NOTCH1 and cancer.