AKR1B1 and amyotrophic lateral sclerosis: Riluzole is currently on the market for the treatment of amyotrophic lateral sclerosis (ALS) [10,11], Pittsburgh compound B is used as a positron emission tomography (PET) imaging agent for Alzheimer’s disease (AD) [12], and zopolrestat is an effective oral aldose reductase inhibitor, and has research value in the complications of diabetes [13].