CD8A and neoplasm: For example, the CuCo(O)/GOx@PCNs hybrid nanozyme was synthesized based on the Co3O4 nanozyme and achieved the function of oxygen supply, glucose consumption, and photothermal ablation, ultimately inhibiting both the growth of the primary tumor and distal tumor, together with boosting tumor immunity by promoting DC maturation, activating and proliferating CD8+ and CD4+ T cells, and enhancing the secretion of IL-12 and IFN-γ to interfere with tumor angiogenesis [105] (Figure 9).