AKT1 and gastric cancer: Tao et al. (2019) [354] reported that aloin induced HGC-27 human gastric cancer cell apoptosis by downregulating expressions of High Mobility Group Box 1 (HMGB1) and RAGE, inhibiting HMGB1 release and suppressing rhHMGB1-induced activation of the AKT/mTOR-P70S6K and ERK-P90RSK-CREB signaling pathways.