Dong Wook Lim et al. discovered that CRP ethanol extract significantly inhibits the loss of bone mineral density (BMD); decreases serum levels of alkaline phosphatase (ALP), type I collagen C-terminal peptide (CTx), and osteocalcin (OC); and improves lipid metabolism and bone metabolism in ovariectomized (OVX) animal models, suggesting its use as a novel osteoporosis inhibitor [95]. This evidence concerns the gene BGLAP and osteoporosis.