Furthermore, TGFB1 has been implicated in adipose dysfunction under conditions of obesity, evidenced by the reduced expression of adipogenic marker genes (ADIPOQ) in mouse adipocytes treated with TGFB1 [44] and increases in Tgfb expression in adipose tissue of obese mice [45]. Here, TGFB1 is linked to obesity due to melanocortin 4 receptor deficiency.