In the present study, this finding could not be identified, as the treated groups did not obtain a significant statistical difference between them, which demonstrates that the amantadine antioxidant pathway releases antioxidant enzymes in chemotherapy-induced neuropathy, with a significant increase in SOD and CAT in the tested groups, but not GPx, thus encouraging further research based on this pathway for onward elucidation. The gene discussed is SOD1; the disease is neuropathy.