CCL3 and neuropathy: Pro-inflammatory cytokine expressions of IL-6, TNF-α and MIP-1α, tested through an immunohistochemical technique, demonstrated a statistically significant increase (p = 0.0001) in groups that received a daily intraperitoneal injection of vincristine, evidencing the increase in these cytokines in the inflammatory process of chemotherapy-induced neuropathy (Figure 2).