MITF and Werner syndrome: Variants in PAX3, SOX10, MITF, EDN3, EDNRB, and KITLG genes have been associated with Waardenburg syndrome (WS) in humans, a group of auditory–pigmentary disorders characterised by various features, including blue eyes or heterochromia (one blue or partially blue eye), sensorineural deafness, a white forelock, and the lateral displacement of the inner canthi of eyes (dystopia canthorum).