However, other chromosomal loci including TM6SF2, SUGP1, PBX4, ZNF101, ZNF512, LOC124904656, HAPLN4, GATAD2A, C2orf16, and TRIB1 that were identified as associated with NAFLD in various NAFLD cohorts were significantly associated with MASLD (Fig. S4). This evidence concerns the gene HAPLN4 and metabolic dysfunction-associated steatotic liver disease.