Intravitreal faricimab (Vabysmo, F. Hoffmann-La Roche AG, Basel, Switzerland) is a novel anti-angiopoietin-2 (Ang-2) and anti-VEGF bispecific agent approved by Food and Drug Administration (FDA) and European Medicines Agency (EMA) for treatment of nAMD and diabetic macular edema (DME). Here, ANGPT2 is linked to diabetic macular edema.