Weight loss is the first non-pharmacological treatment for infertility in obese women with PCOS, while clomiphene citrate (anti-estrogen), aromatase inhibitors (estrone and estradiol reducing), gonadotropins (stimulating ovulation) and metformin (lowering blood sugar) can be effective pharmacological treatments for infertility due to PCOS [12]. Here, CYP19A1 is linked to polycystic ovary syndrome.