Additionally, 14 KEGG functional genes showed significant differences between tumor and HC samples, which were predominantly characterized by the upregulation of large subunit ribosomal proteins (RPs) such as L10e, RP-L6e, RP-L5e, and RP-L18Ae in the tumor samples, together with the depletion of RP-L40e and RP-L30e. The gene discussed is LARGE1; the disease is neoplasm.