Multivariable Cox analysis and related forest plots described that PTCSC3 (P = 0.01), TNM stage (P = 0.03), lymphatic metastasis (P = 0.03) and Gleason score (P = 0.04) are independent prognostic factors for prostate cancer (Fig. 1d; Table 2). Here, PTCSC3 is linked to Familial prostate cancer.