Molecular docking studies confrmed that the three active components of astragalus have good binding activities with their corresponding targets.<h4>Conclusions</h4>Apigenin, Baicalein and Wogonin, important active components of Scutellaria Radix, produce anti-sepsis effects by regulating the expression of their targets CFLAR, EGLN1 and PRKCD. This evidence concerns the gene CFLAR and Sepsis.