Our assays yielded similar results, and we further presented that the oncogenic effects of FAM84B were related to the eccDNA since the knockdown of Lig3, the ligase that is responsible for the generation of eccDNA, contributed to the less malignant phenotype of PCa cells, which was overturned by FAM84B overexpression. The gene discussed is LRATD2; the disease is posterior cortical atrophy.