Copy number gains involving high-level amplifications at 8q21 and 8q24 have been frequently reported in breast cancer, and the breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative targets tumor protein D52 and WW domain-containing protein 1 (WWP1) [12]. The gene discussed is WWP1; the disease is breast cancer.