TARDBP and amyotrophic lateral sclerosis: The cytoplasmic inclusions are either diffuse/granular, skein-like or round in morphology and the constituent TDP-43 protein molecules are polyubiquitinated, hyperphosphorylated, in part fragmented with a significant presence of C-terminal fragments, acetylated, SUMOylated, citrullinated and monomethylated [1–3, 6–10], with fragmentation observed particularly in the brain and more rarely in the spinal cord in ALS patients [11].