HSPA1A and rheumatoid arthritis: Through phenome-wide scanning, we found that two of the above five genes were associated with multiple phenotypes (p < 5E-08): HSPA1A is associated with several immune diseases, such as celiac disease, rheumatoid arthritis (RA), psoriasis, and multiple sclerosis (MS), suggesting that the different expression levels of HSPA1A may cause an imbalance of immune homeostasis and mediate a wide range of immune-related illnesses.