As the first study in the field of SLE to integrate GWAS, gene expression eQTLs, and pharmacogenomic data to explore drug targets, we conducted a systematic analysis of the causal associations between 5427 druggable genes and SLE risk, ultimately identifying five potential therapeutic targets (BLK, HIST1H3H, HSPA1A, IL12A, NEU1). The gene discussed is NEU1; the disease is systemic lupus erythematosus.