However, the frequencies of RORC+TBX21− TH17 and FOXP3+ Treg were higher in nonprogressors than progressors (TH17, 16.0% versus 13.3%, P = 0.01 and Treg, 3.01% versus 2.40%, P = 0.07) (Fig. 6c), indicating that RSTR-defined Treg cell-like and TH17 cell-like phenotypes were enriched in South African adolescents with LTBI who did not progress to active TB disease. The gene discussed is RORC; the disease is tuberculosis.